Study of the effect of Ethanolic extract of pomegranate peels on some blood serum biochemical parameters in alloxan induced diabetes male rats

  • Mohanad M. Jandal Food Sciences Dept., College of Agriculture, University of Tikrit, Tikrit, Iraq
  • Ethar Z. Naji Food Sciences Dept., College of Agriculture, University of Tikrit, Tikrit, Iraq

Abstract

This study was conducted in at the Biotechnology Research Center / Nahrain University / Baghdad Governorate, for the period 2/8/2020 to 15/9/2020, the follow of the effects of dosing with ethanolic extract of pomegranate peels on 30 male rats of (2-3) months of age and weights (170-220 g) were included, it was divided into two parts, one of which is intact and the other in which diabetes was introduced by using alloxan at a concentration (90 mg / kg) of body weight, The results showed of the biological study that the development of experimental diabetes showed significant increase (P <0.05) in the concentrations of Glucose, Total cholesterol (TC), Trigleserid (TG), low-density lipoproteins cholesterol (LDL-C), Very-low-density lipoprotein cholesterol (VLDL-C), and the enzymes of aspartate transaminase and alanine transaminase (AST وALT), and malonedialdehyde concentration (MDA), Compared with a intact control group, while it led to a significant decrease (P <0.05) in body weight, insulin concentration, high-density lipoprotein cholesterol (HDL), in the affected control group. Dosing in intact rats with ethanolic extract of pomegranate peel at a concentration of 75 and 150 mg / kg of body weight led to a significant decrease in the concentrations of glucose, TC, TG, LDL-C and VLDL-C, as well as AST, ALT, and MDA enzymes, compared with a healthy control group, Significant increase in body weight, insulin and HDL-C concentrations for all treatments compared with the healthy control group. Dosing of diabetic rats with ethanolic extract of pomegranate peels at a concentration of 75 and 150 mg / kg of body weight led to a significant decrease in the concentrations of glucose, TC, TG, LDL-C and VLDL-C, as well as AST, ALT, and MDA enzymes, compared with the infected and untreated control group, a significant increase in body weight, insulin and HDL-C concentrations, for all treatments, compared with the affected control group.

Published
Apr 8, 2021
How to Cite
JANDAL, Mohanad M.; NAJI, Ethar Z.. Study of the effect of Ethanolic extract of pomegranate peels on some blood serum biochemical parameters in alloxan induced diabetes male rats. Tikrit Journal for Agricultural Sciences مجلة تكريت للعلوم الزراعية, [S.l.], v. 21, n. 1, p. 138-151, apr. 2021. ISSN 2664-0597. Available at: <http://tujas.tu.edu.iq/index.php/ph/article/view/485>. Date accessed: 25 sep. 2022. doi: http://dx.doi.org/10.25130/tjas.v21i1.485.